Department of Chemistry

School of Natural Sciences and Mathematics

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Jiyong Lee, Ph.D.

Chemical Biology

Research Group

Group webpage


B. S. 1999, Yonsei University
M. S. 2001, Yonsei University (Advisor: Injae Shin, Ph.D.)
Ph.D. 2009, UT Southwestern Medical Center (Advisor: Thomas Kodadek, Ph.D.)
PostDoc. 2012, The Scripps Research Institute (Advisor: Jeffery W. Kelly, Ph.D.)

Research Description

Our research goal is to develop novel chemical biology technologies and small molecules in order to probe the molecular mechanisms of cancer metastasis, drug resistance, and recurrence. Current projects include:

  • Construction of novel combinatorial chemical libraries.
  • Discovery of novel small molecule modulators of autophagy for the treatment of cancers and neurodegenerative diseases.
  • Discovery of small molecule modulators of cancer stem cells.

Selected Publications

Lee, J., Culyba, E. K., Powers, E. T., Kelly, J. W., Amyloid-β forms fibrils by nucleated conformational conversion of oligomers , Nature Chemical Biology, 2011, 7, 602-609.
* Featured in Nature Chemical Biology News and Views: “FlAsH illuminates Aβ aggregation”, by Tiago F Outeiro.
*Evaluated in Faculty of 1000 by Alan Saghatelian.

Lee, J., Udugamasooriya, D. G., Lim, H-S., Kodadek, T., Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates, Nature Chemical Biology, 2010, 6(4), 258-260.
* Evaluated in Faculty of 1000 by Divya Krishnamurthy, Amy Barrios, and Ross Weatherman.

Lee, J., Reddy, M. M., Kodadek, T., Discovery of an orexin receptor positive potentiator, Chemical Science, 2010, 1(1), 48-54.
* Featured as an inside cover article.

  • Updated: December 4, 2015
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